![]() ![]() The compensation we receive from advertisers does not influence the recommendations or advice our editorial team provides in our articles or otherwise impact any of the editorial content on Forbes Advisor. Second, we also include links to advertisers’ offers in some of our articles these “affiliate links” may generate income for our site when you click on them. This site does not include all companies or products available within the market. The compensation we receive for those placements affects how and where advertisers’ offers appear on the site. First, we provide paid placements to advertisers to present their offers. This compensation comes from two main sources. To help support our reporting work, and to continue our ability to provide this content for free to our readers, we receive compensation from the companies that advertise on the Forbes Advisor site. The Forbes Advisor editorial team is independent and objective. Zoho Invoice also allows you to track time spent working on projects and bill clients by project or task. Payment gateways charge their own separate payment processing fees (usually around 3% for payments by credit card and 1% for payments by ACH bank transfer), but this is standard in the industry. It allows you to auto-charge customers at recurring intervals, send payment reminders, record off-line payments and collect advanced payments. Zoho supports ten payment gateway options including Stripe and PayPal. Finally, you’ll also be able to send invoicing reminders. A reporting dashboard allows you to glean insights about the status of your invoices and financials. You’ll be able to convert your estimates into an invoice, and keep track of your project estimate history and interaction between clients. Zoho also comes with the ability to create project estimates, with an overview of details like prices, discounts, terms and conditions. The customization options allow you to change the way the item table looks, create invoices in multiple languages and bill in different currencies, include tax-related information on your invoice and customize different invoices according to clients. ![]() To create an invoice, you can choose between a selection of templates and then customize each one according to your business’s brand and aesthetic-a great way to add a professional touch to your invoicing process. The platform allows you to accept payment, keep a record of invoices sent and received, as well as record off-line payment, view invoice history and keep track of payments. Zoho allows you to send up to 1,000 invoices per year. Whether you are used to manually creating each invoice, struggling to keep track of payments or simply want to upgrade the level of professionalism in your business, the invoice templates and software Zoho provides-at no cost-is a great tool to achieve all of the above. Zoho Invoice is free invoicing software that offers the ability for freelancers and small business owners to manage their accounting in an organized and professional way.
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As a result of this, the Medical Director should be perceived as a scientific expert and strategist, both internally and externally. From a practical standpoint, they also need to be aware of the important role of payers and insurance companies, and cognisant of the challenges that patients and caregivers face. The Medical Director, therefore, must have in-depth expertise in disease management and an aptitude and interest in at least one clearly defined therapeutic area, understanding how future therapies will evolve. Additionally, our understanding of disease biology and the development of personalised medicines has deepened further. The scientific expert: Rapid advancements in science have led to specialised medicines becoming an important portfolio for most pharmaceutical organisations. 1): as a scientific expert, a conscience keeper, the external face of the organisation and a people leader. Overall, the role of a Medical Director can be categorised into four clear quadrants (as demonstrated in Fig. This article is mainly focused on Medical Directors leading the Medical Affairs function at country or cluster level, although broad principles can be applied to Medical Directors performing many other regional or global roles. However, in recent times, the rapid evolution of Medical Affairs has made it the most prominent, strategic and standalone function in a country. Historically, Regulatory, Clinical Research, Pharmacovigilance and Medical Affairs have emerged from the same team. Typically, a Medical Director leads the Medical Affairs department, although specific designations can vary subject to the organisation or geography. The pharmaceutical industry operates through multiple offices across multiple countries, and sometimes in clusters of more than one country. Changes in regulations, expectations of internal and external stakeholders and types of portfolio have resulted in the evolution of the function. Medical Affairs is now the cornerstone function in the pharmaceutical industry. Energy management in physical, mental, emotional and spiritual domains is the way forward. To excel in their function, current and future Medical Directors need to sharpen their existing skills and build specific capabilities. Each of the seven habits can be adapted and utilised to shape the specific areas that Medical Directors are responsible for: intuitive creativity, patient centricity, prioritisation, enterprise leadership, communication and behavioural change, building a team, partnering and scientific and technological leadership. As scientific, functional and enterprise leaders, country and cluster Medical Directors must possess these seven qualities. The capabilities described in the book The 7 Habits of Highly Effective People® are not just the integral qualities of a successful leader, they are important capabilities that are critical to becoming an impactful medical leader too. Other perks such as health memberships and insurance should be utilised also.Medical Directors in the pharmaceutical industry are responsible for fulfilling multiple roles, including scientific expert, conscience keeper and people leader, as well as being the external face of the organisation. ![]()
![]() Breeds at higher than average risk for congenital liver shunts include the Yorkshire Terrier, Dachshund, Maltese, Miniature Schnauzer, Lhasa Apso, Bichon Frise, Shih Tzu, Havanese, Toy and Miniature Poodle, Pekingese, Dandie Dinmont Terrier, Australian Cattle Dog, Australian Shepherd, Irish Wolfhound, Old English Sheepdog, Samoyed, Irish Setter, Labrador Retriever, Doberman Pinscher, Golden Retriever, and German Shepherd.Īcquired shunts typically develop when blood pressure within the veins connecting the digestive tract to the liver becomes elevated-most often because of diseases that cause liver scarring (cirrhosis). A genetic cause is known for some breeds and suspected in others. Dogs are usually quite young (less than 3 years old) when they start experiencing symptoms. Liver shunts can be divided into two categories: those that are present at birth (congenital shunts) and those that develop later in life (acquired shunts).Ĭongenital shunts are most common, being responsible for approximately 80 percent of cases. The liver takes what it needs to function properly and also detoxifies the blood before sending it onward.Ī shunt is defined as a passage “that allows the flow of materials between two structures that are not usually connected.” A portosystemic shunt is, specifically, an abnormal blood vessel (or vessels) that connects the “portal” system draining the digestive tract to the “systemic” circulatory system feeding the rest of the body, thereby bypassing the liver. This blood carries nutrients, hormones, and waste material and is supposed to enter the liver before it travels to the rest of the body. A network of veins (called the portal system) drains blood away from the digestive tract. What Is a Liver Shunt?įirst, we need to review some canine anatomy and physiology. Read on to learn all about liver shunts in dogs. Liver shunts (technically called portosystemic shunts) are not that common in dogs, but if you are an aficionado of certain breeds or if your dog develops liver disease, you may find yourself in desperate need of information. Pick 4 is operated by the Western Canada Lottery Corporation. 5,000 or more with Fireball LAST DRAW RESULTS: MIDDAY () 4 3 7 6 3 FIREBALL EVE () 2 2 0 7 3 FIREBALL Drawings 2x Daily. Pick 4 is not available to players outside of Western Canada Lottery Corporation provinces however, a game of the same name with a similar format is available to players in Ontario. Players must be at least 18 years of age to play Pick 4, with tickets sold at lottery retailers in Alberta, Saskatchewan, Manitoba, Yukon, the Northwest Territories and Nunavut. Prizes are paid out as tax-free lump sums. View past winning numbers on one of the Last 180 Days game pages: Powerball, Mega Millions, The Pick, Fantasy 5, Pick 3 or Triple Twist. Prize winners have up to one year to make a claim. It is only possible to win the jackpot by playing Straight Play, with the four secondary prizes only available through Box Play. The odds of winning the Pick 4 jackpot are 1 in 1,000. Pick 4 has a fixed jackpot of CAD 5,000, with no rollovers or roll downs if the prize fails to be won. Players can choose Advance Play for up to 25 draws at a time. Extra offers a second prize of CAD 100,000 for matching the last six digits, with five further secondary prizes also being available. ![]() The Extra game costs an additional CAD 1.00 per Pick 4 game, with players receiving a random seven-digit number printed on their ticket for a chance to win the CAD 250,000 jackpot. Players can choose Straight Play for a chance to win the jackpot, or Box Play to open up secondary prize tiers. Players choose four numbers from 0 to 9,or go for a Quick Pick for randomly generated ones, and because each number is chosen independently, it is possible to choose four of the same. Pick 4 is a daily game available in Alberta, Saskatchewan, Manitoba, Yukon, the Northwest Territories and Nunavut.ĭraws take place in Winnipeg at 21:30 Central Time/20:30 Mountain Time/19:30 Pacific Time, with ticket sales closing just before the draw and reopening immediately afterward. If you're keen to game while on the move, you need a sweet gaming laptop. ![]() Speck announces collapsible Pocket VR viewer Lenovo gives a peek at the first Windows Holographic VR headset at CES 2017 Whether it’s the starting fluid of an enormous and profitable VR media industry or the final, crushing blow to the already-plummeting birthrates of many industrialized nations, the future of pornography is here, available now in a private VR fantasia near you. According to Paul there are two other, smaller companies currently working on porn VR, but they have neither Naughty America’s stable of star power or market penetration. VR videos can be accessed as part of the standard monthly site membership. It launched in July, and new content rolls out at a rate of roughly one video per week. Not just a distant concept, this glorious future of immersive smut is available now - six months ago, in fact. Warning: The following trailer isn’t explicit, but you probably still don’t want your boss to see you watching it. Paul certainly sees VR as a sea change for the industry: “The entire history of porn has been trying by whatever means available to arrive at this type of experience, and now it’s here. Porn is already a $3.3 billion annual industry, ravenously expanding to fill all channels available. While gaming has driven the initial advances in VR technology, porn’s popularity and obvious synergy with the medium will likely make it an important factor for many people getting on board. When asked about the possibility of same-sex content, Paul mentioned 360-degree views as something coming down the pipe that would help enable it, allowing for full immersion in a virtual bacchanal. As a starting point, it’s very convincing, and it will only improve. As for how they are filmed, “a combination of off-the-shelf and custom parts” is as specific as Naughty America CIO Ian Paul told me. ![]() My demonstration was on a Samsung Gear VR, but the videos are compatible with virtually any headset on the market now, from the humble Google Cardboard up to a fancy Oculus Rift. In addition to opening up whole new avenues of kink, the ability to viscerally inhabit bodies unlike our own has compelling implications for how VR experiences could be used to cultivate empathy. Inhabiting a female form, mounted by a musclebound stud is far afield from my typical sexual experience. For me, the female perspective video was perhaps the most interesting, because it offered me a kind of out-of-body experience I have never had before. I watched compilation demo reels from both the male and female perspective. It’s startling to encounter them at true, human scale - sweaty, doubly-artificial breasts bobbing inches from your face.Īll of the content is heterosexual, mainstream porn, in line with the site’s predominant user-base, with the promise of greater diversity and more genre representation as the VR market grows. Unless you watch on a very large screen, people in porn videos are almost always quite small, relatively speaking. The sense of scale was perhaps the most striking part. Even having experienced a lot of virtual reality over the previous few days, my imagination could not prepare me porn calls upon very animal parts of the brain, so to encounter it in such a personal way is visceral. More than just being up close and personal with a POV video, VR porn is a different beast all its own. It’s difficult to communicate in writing just how jarring the experience was. Updated HTC Vive Headset and Controllers Leak Ahead of CES 2016 Get ready for Android VR: Google may unveil a stand-alone VR headset at I/O 2016 Looking down, you see your toned, virtual body, sitting or lying back passively as sex happens all up on you. You can look around freely for 180-degrees in front of you, the room just ending in a hard black plane around the periphery of your vision. You find yourself in a room, unable to move. POV (point of view) is already a major keyword in online porn, but VR takes the genre to a whole new level. I tried virtual pornography last week in a hotel room cocktail party at CES. It should come as no surprise then that here at the dawn of feasible, widespread virtual reality, leading porn producer Naughty America is ready with VR porn for the masses. Look back as far as ancient cave paintings and you can find sex it’s one of the first things we do with any new medium. Throughout the last few decades, the pornography industry has been an aggressive early adopter of emerging media technology, accelerating the general adoption of formats like VHS, DVD, and streaming video. ![]() If you are in the Jacksonville, FL area and you’re considering working with a psychotherapist, counselor, social worker, clinical psychologist, psychiatrist, or family therapist, reach out to Thriveworks Counseling & Psychiatry Jacksonville. Schedule a Therapy or Counseling Appointment at Thriveworks Counseling & Psychiatry Jacksonville Make an online therapy appointment today with Thriveworks Counseling & Psychiatry Jacksonville to speak with a licensed psychiatrist. They can even directly prescribe medication if your treatment calls for that. Psychiatrists use that information to diagnose mental health concerns and tailor a treatment plan. As licensed medical doctors, psychiatrists can evaluate symptoms and complications related to your mental health and customize treatment as a result.Įvaluation typically involves a client’s self-reporting, some kind of psychological testing, or both. Psychiatry deals with mental and emotional health from a medical perspective. Should I Make an Appointment With a Psychiatrist?Īre you dealing with anxiety, depression, substance abuse, or another mental health concern? If so, visiting with a licensed psychiatrist may be the best course of action. Here’s a list of the main mental health services offered at Thriveworks Counseling & Psychiatry Jacksonville: We are here to help, and we are sympathetic to the various issues that our patients face on a daily basis. The first step to getting started with our therapy, counseling, or life coaching services at Thriveworks Counseling & Psychiatry Jacksonville could not be simpler-let your loved one know that they can simply give us a call and speak with a member of our friendly staff. ![]() By being a supportive and understanding companion for your loved one in their time of need, it may be easier for them to get the help they require to turn their life around. It may only require the encouragement of a trusted family member or friend to convince someone that they should seek treatment for their problems. If you have noticed that a loved one in your life seems to be struggling with some emotional challenges, consider referring them to our services here in Jacksonville. Your problems are unique to you, so the solution to those problems will need to be unique as well. ![]() Rather than applying a “one size fits all” approach to our mental health services, we are proud to work with each individual as the unique person that they are. When you choose to consult with a counselor or psychologist at Thriveworks Counseling & Psychiatry Jacksonville regarding your issues, you will be helped by a qualified professional who can assist you in working through whatever problems you are facing. Anger problems (e.g., difficulty controlling temper).The potential reasons that you could have in mind for looking into counseling or therapy are too numerous to list in full, but the following list includes some of the most common issues faced by our patients: Everyone in and around Jacksonville deserves to live the life they dream of, and we hope to be a small part of making that happen. You can rest assured that our entire team will be committed to helping you reach the outcome you desire. Whether that comes in the form of a broken relationship, a lost career, a mental illness, or something else entirely, a qualified therapist may be able to help. Therapy is a smart choice for anyone dealing with some form of emotional pain or challenge. It only takes a quick call to get started, so we hope that we will hear from you soon! Do I Need Therapy? Could I Benefit from Thriveworks Mental Health Services? Our staff will be happy to help you find the right treatment for your needs, be it individual therapy, life coaching, couples therapy, marriage counseling, therapy for depression, online counseling, child and teen therapy, work with a psychologist, psychiatry counseling, or another Thriveworks mental health service. If you need to get your life moving in the right direction once again-even if you don’t know what is wrong at the moment-please feel free to reach out to Thriveworks Counseling & Psychiatry Jacksonville. This is where a counselor or therapist can be helpful. Often, human beings find that they don’t feel “quite right” about life, but they aren’t sure what is wrong either. ![]() Understanding yourself can be one of the most challenging parts of life. Social deficits reflect difficulty expressing reciprocal verbal and non-verbal behaviour, but patients may also show rigidity in behaviour and hypersensitivity to external stimuli 3. In tandem, ASD is a neurodevelopmental condition predominantly characterised by a wide range of pathological social and behavioural impairments. AN affects 8 in 100,000 people, and has the highest mortality rate of any psychiatric illness at 20% 1, 2. This psychiatric condition results in extremely low body weight in the context of individual age, sex, and overall development. Findings suggest no consistent neuroanatomical abnormality associated with ASD, and evidence is lacking to suggest that reported behavioural similarities between those with AN and ASD are due to neuroanatomical structural similarities.Īnorexia nervosa (AN) is a severe and multifactorial eating disorder characterised by a pathological fear of putting on weight and a distorted body-image. There was no structural overlap between ASD and AN. The changes are consistent with alterations in flexible reward-related learning and episodic memory reported in neuropsychological studies. Meta-analysis of 23 AN publications revealed increased volume within the orbitofrontal cortex and medial temporal lobe, and adult-only AN literature revealed differences within the genu of the anterior cingulate cortex. Across 46 ASD publications, a meta-analysis of volumetric differences between ASD and healthy controls revealed no consistently affected brain regions. ![]() ![]() ![]() We performed a systematic review of structural MRI literature with the aim of identifying common structural neural correlates common to both AN and ASD. Some behaviours, particularly concerning food selectivity are found in populations with both Autism Spectrum Disorder (ASD) and AN, and there is a proportionally elevated number of anorexic patients exhibiting symptoms of ASD. Recent research reports Anorexia Nervosa (AN) to be highly dependent upon neurobiological function. ![]() Silkies are a ubiquitous breed and there is no doubt about it that it is a very old breed that was first discovered in China. If you’re looking for a really special and out of the ordinary chook to add to your backyard flock, you cannot go wrong with these fluffy beauties.īy the end of this article, you will be dying to add a Silkie to your flock – or to just run out and buy more because they are some of the best backyard additions you could hope for! Their feathering sets them apart from regular chickens, but Silkies are also unusual in the sense that they have black skin, blue earlobes, extra toes and an inability to fly.Ī cheeky little head-turner, Silkie chickens delight their owners with their cute looks, friendly disposition, docile nature and adaptability. Silkie chickens are known for their characteristically fluffy plumage said to feel silk- or satin-like to the touch. Or perhaps you’re just a fan of these cute little critters and wondering what they’re like in the egg production department? It doesn’t matter what brought you here, what’s going to keep you here is the fact that myself and my poultry peeps collectively have more than 30 years’ experience with these fantastic little birds and can truly consider ourselves Silkie Chicken Experts! So, we can tell you all about this breed along with all the delicious details regarding their adorable eggs. So, you’re here because you want to learn about Silkie eggs? Yes, these little fluffy chickens are also capable of laying eggs for you and your family, that’s part and parcel of what makes them such highly sought-after family pets. ![]() Which came first the chicken or the egg? While this is an egg-sestential question, for the purposes of this article, let’s say that the egg came first. ![]() Background Information on the Silkie Breed Though the decline is even worse for some Gannett papers. 6, 2022 edition of the paper shows that it averaged 56,989 total paid print and digital subscribers in the preceding 12 months, a figure midway between the daily and Sunday circulation figures reported by Gannett.Īll of which shows there has been a catastrophic decline in the JS circulation. The most recent statement filed by the Journal Sentinel and published in its Oct. The form warns that “anyone who furnishes false or misleading information… or who omits material or information requested on the form may be subject to criminal sanctions (including fines and imprisonment)…” A print subscriber with free access to the electronic version of your paper cannot be counted as a paid e-Subscriber.” The guidelines for this require that “A paid subscriber, electronic or print, may only be counted once. Postal Service in the “Statement Of Ownership, Management and Circulation” which newspapers must annually publish. This puts the latest numbers more in line with those required by the U.S. In 2022, it noted, “digital access is no longer tracked” but “average circulation in print, digital replica” and “digital non-replica” is included. The decline for the most recent year may have been even greater because of a change in how Gannett counted: in 2021, it appears, it included “digital access” as a category of subscriber, presumably meaning print subscribers who also have digital access. In 10 years the JS has lost 74% of its daily paper readers. In 10 years the JS has lost 75% of its Sunday readers. The newspaper has seen its Sunday circulation plummet in 10 years from 299,000 in 2012 to 170,791 in 2018 to 129,887 in 2020 to 75,016 as of last fall. That’s down from a Sunday circulation of 115,026 in the previous year (September 2021), as the prior year’s report by Gannet shows, which is a decrease of nearly 35%, with a loss of nearly 40,000 subscribersĪnd that’s down from a daily circulation of 75,676 in the previous year, a decline of 36%, with a loss of 27,518 subscribers. The latest Form 10-K report required by the federal SEC and published by Gannett shows the Journal Sentinel now has a “combined” (print and digital) Sunday circulation of 75,061 and a combined daily circulation of 48,158 as of September 2022. Its parent company Gannett shows plummeting readership for the many papers it owns, including the Milwaukee Journal Sentinel, one of the national chain’s biggest daily newspapers. The latest circulation numbers for the Milwaukee Journal Sentinel are jaw dropping. For more information, visit and interact with us on social media: Facebook, Instagram, TikTok, Twitter and YouTube.330 Kilbourn, where the Journal Sentinel offices are located. The company also markets under the Briarpatch, Forbidden Games, Front Porch Classics, Great Explorations and Bepuzzled brands in the US, UK, Canada, Australia and throughout the world. It'll be all you can gather to collect eight completed jokes to win.īob Moog's Dad Jokes Game is joined this year by other new party and strategy games from University Games including The Rocky Horror Show Game, Irritable Vowels, Relist It, Happy Hour Hustle, Mosaic: A Story of Civilization, Murder Mystery Party Mission Black Hawk Case Files and The Night Hunter Game.Ībout University Games: University Games is a leading game and puzzle publisher founded in 1985 by Bob Moog and Cris Lehman. To play the Dad Jokes Game, players try to match the Dad wisdom cards with the appropriately groaning punchlines. The game includes all of Bob Moog's favorites and if we missed any of yours, it just wasn't in the cards." "Between our company president and the magic of our staff, the game wound up creating itself," Craig Hendrickson, SVP Product Development at University Games, said, "We had so many great jokes to choose from. ![]() University Games' Dad Jokes Game, for 2-6 players ages 8+, is just $15, which isn't much for Dad's cents of humor. Then I perfected the art with my three daughters over the last 30 years." ![]() "I was creating 'Dad Jokes' since before I was a Dad. "We've put the puns to good use," Moog, president of University Games, said. The new game contains all the best and worst Dad jokes, written and collected by toy industry veteran, long-time Dad, and game design extraordinaire Bob Moog. University Games today announced the birth of its newest game and it is now a-parent that the Dad Jokes Game will be ready for retail in time for Father's Day. () This Father's Day, the joke's for Dad. ![]() ![]() You can win prizes in both Double Play and the main draw with the same set of numbers. The overall odds of winning a Double Play prize are approximately 1 in 24.9 The odds of winning are the same for both draws. The following table shows the prizes available in Double Play, along with the corresponding prizes for the main drawing. If there are multiple winners, the jackpot is split between them. This stays as a fixed amount in every drawing, even if nobody wins. The Double Play jackpot is $10 million and you win by matching all five main numbers and the Powerball. For example, if you match the Powerball on its own without any of the main numbers, you win $7 in Double Play compared to $4 in the main draw. In fact, the Double Play payouts are worth more than the equivalent Powerball payouts for six of the nine prize levels. Just like the main Powerball game, there are nine different ways to win prizes in Double Play based on how many numbers you match. It is held shortly after the main drawing. The Double Play draw works in the same way as the main draw, with five numbers from 1 to 69 and a Powerball number from 1 to 26 selected at random. The numbers you select for the main Powerball drawing are also entered into the Double Play drawing that takes place on the same night. Double Play entries do not include Power Play.You can’t play Double Play as a standalone game.You don’t pick a different set of numbers for Double Play.The cost of entry is an additional $1 per play.Here are some more points you need to know about the game: All you need to do is select the Double Play option on your playslip to be entered into the second chance draw. If Double Play is available in your state, it couldn’t be simpler to take part. |
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